Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson's disease
Identifieur interne : 001B42 ( Main/Exploration ); précédent : 001B41; suivant : 001B43Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson's disease
Auteurs : Randolph Stephenson [États-Unis] ; David Houghton [États-Unis] ; Sri Sundarararjan [États-Unis] ; Richard L. Doty [États-Unis] ; Matthew Stern [États-Unis] ; Sharon X. Xie [États-Unis] ; Andrew Siderowf [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-10-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Cognition Disorders (etiology), Cohort Studies, Complication, Confidence Intervals, Dementia, Disease Progression, Dyskinesias (etiology), Female, Hallucinations (etiology), Human, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Nervous system diseases, Odor, Odors, Olfaction, Olfaction Disorders (etiology), Parkinson Disease (complications), Parkinson disease, Parkinson's disease, Risk Factors, Risk factor, Visual hallucination, dementia, olfaction, visual hallucinations.
- MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Dyskinesias, Hallucinations, Olfaction Disorders.
- Aged, Cohort Studies, Confidence Intervals, Disease Progression, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Odors, Risk Factors.
Abstract
Olfactory deficits appear early in the course of Parkinson's disease (PD) but their prognostic significance is not known. The goal of this study was to determine whether the severity of olfactory impairment is associated with subsequent risk of developing complications of PD. One hundred patients with PD self‐administered the University of Pennsylvania Smell Identification Test (UPSIT). Testing was done, on average, 3.6 years from the time of initial diagnosis. The incidence of neuropsychiatric features of PD, including cognitive decline and visual hallucinations, was ascertained through chart review after an average of 6.8 years of follow‐up. Incidence of motor outcomes including falls and dyskinesias was also obtained. There was a significant trend for increased risk of neuropsychiatric complications across declining quartiles of olfactory test scores. In addition, subjects in the lowest quartile of olfactory performance had a significantly higher adjusted risk of hallucinations (HR = 4.70, 95% CI 1.64, 13.42) and cognitive decline (HR = 3.10, 95% CI 1.05, 9.21) than those in the reference quartile. There was no association between olfactory dysfunction and dyskinesias, and a very modest association with risk of falls. These findings suggest that severity of olfactory impairment early in the disease course may be a useful marker for the risk of neuropsychiatric complications of PD. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/3731A899623CB2E0CEE10F1B602A89581A3A3017/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963102
DOI: 10.1002/mds.23234
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001240
- to stream Istex, to step Curation: 001240
- to stream Istex, to step Checkpoint: 000821
- to stream Pmc, to step Corpus: 000105
- to stream Pmc, to step Curation: 000105
- to stream Pmc, to step Checkpoint: 000322
- to stream PubMed, to step Corpus: 001683
- to stream PubMed, to step Curation: 001683
- to stream PubMed, to step Checkpoint: 001739
- to stream Ncbi, to step Merge: 002D34
- to stream Ncbi, to step Curation: 002D34
- to stream Ncbi, to step Checkpoint: 002D34
- to stream Main, to step Merge: 001F78
- to stream PascalFrancis, to step Corpus: 000882
- to stream PascalFrancis, to step Curation: 002437
- to stream PascalFrancis, to step Checkpoint: 000933
- to stream Main, to step Merge: 002520
- to stream Main, to step Curation: 001B42
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson's disease</title><author><name sortKey="Stephenson, Randolph" sort="Stephenson, Randolph" uniqKey="Stephenson R" first="Randolph" last="Stephenson">Randolph Stephenson</name></author><author><name sortKey="Houghton, David" sort="Houghton, David" uniqKey="Houghton D" first="David" last="Houghton">David Houghton</name></author><author><name sortKey="Sundarararjan, Sri" sort="Sundarararjan, Sri" uniqKey="Sundarararjan S" first="Sri" last="Sundarararjan">Sri Sundarararjan</name></author><author><name sortKey="Doty, Richard L" sort="Doty, Richard L" uniqKey="Doty R" first="Richard L." last="Doty">Richard L. Doty</name></author><author><name sortKey="Stern, Matthew" sort="Stern, Matthew" uniqKey="Stern M" first="Matthew" last="Stern">Matthew Stern</name></author><author><name sortKey="Xie, Sharon X" sort="Xie, Sharon X" uniqKey="Xie S" first="Sharon X." last="Xie">Sharon X. Xie</name></author><author><name sortKey="Siderowf, Andrew" sort="Siderowf, Andrew" uniqKey="Siderowf A" first="Andrew" last="Siderowf">Andrew Siderowf</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3731A899623CB2E0CEE10F1B602A89581A3A3017</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23234</idno><idno type="url">https://api.istex.fr/document/3731A899623CB2E0CEE10F1B602A89581A3A3017/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001240</idno><idno type="wicri:Area/Istex/Curation">001240</idno><idno type="wicri:Area/Istex/Checkpoint">000821</idno><idno type="wicri:doubleKey">0885-3185:2010:Stephenson R:odor:identification:deficits</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963102</idno><idno type="RBID">PMC:2963102</idno><idno type="wicri:Area/Pmc/Corpus">000105</idno><idno type="wicri:Area/Pmc/Curation">000105</idno><idno type="wicri:Area/Pmc/Checkpoint">000322</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001683</idno><idno type="wicri:Area/PubMed/Curation">001683</idno><idno type="wicri:Area/PubMed/Checkpoint">001739</idno><idno type="wicri:Area/Ncbi/Merge">002D34</idno><idno type="wicri:Area/Ncbi/Curation">002D34</idno><idno type="wicri:Area/Ncbi/Checkpoint">002D34</idno><idno type="wicri:doubleKey">0885-3185:2010:Stephenson R:odor:identification:deficits</idno><idno type="wicri:Area/Main/Merge">001F78</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:10-0474340</idno><idno type="wicri:Area/PascalFrancis/Corpus">000882</idno><idno type="wicri:Area/PascalFrancis/Curation">002437</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000933</idno><idno type="wicri:doubleKey">0885-3185:2010:Stephenson R:odor:identification:deficits</idno><idno type="wicri:Area/Main/Merge">002520</idno><idno type="wicri:Area/Main/Curation">001B42</idno><idno type="wicri:Area/Main/Exploration">001B42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson's disease</title><author><name sortKey="Stephenson, Randolph" sort="Stephenson, Randolph" uniqKey="Stephenson R" first="Randolph" last="Stephenson">Randolph Stephenson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Houghton, David" sort="Houghton, David" uniqKey="Houghton D" first="David" last="Houghton">David Houghton</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Louisville School of Medicine, Louisville, Kentucky</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Sundarararjan, Sri" sort="Sundarararjan, Sri" uniqKey="Sundarararjan S" first="Sri" last="Sundarararjan">Sri Sundarararjan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Doty, Richard L" sort="Doty, Richard L" uniqKey="Doty R" first="Richard L." last="Doty">Richard L. Doty</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Smell and Taste Center and Departmnet of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Stern, Matthew" sort="Stern, Matthew" uniqKey="Stern M" first="Matthew" last="Stern">Matthew Stern</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Xie, Sharon X" sort="Xie, Sharon X" uniqKey="Xie S" first="Sharon X." last="Xie">Sharon X. Xie</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Morris K. Udall Center of Excellence in Parkinson's Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Siderowf, Andrew" sort="Siderowf, Andrew" uniqKey="Siderowf A" first="Andrew" last="Siderowf">Andrew Siderowf</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Morris K. Udall Center of Excellence in Parkinson's Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-15">2010-10-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="2099">2099</biblScope><biblScope unit="page" to="2104">2104</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3731A899623CB2E0CEE10F1B602A89581A3A3017</idno><idno type="DOI">10.1002/mds.23234</idno><idno type="ArticleID">MDS23234</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognition Disorders (etiology)</term><term>Cohort Studies</term><term>Complication</term><term>Confidence Intervals</term><term>Dementia</term><term>Disease Progression</term><term>Dyskinesias (etiology)</term><term>Female</term><term>Hallucinations (etiology)</term><term>Human</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Odor</term><term>Odors</term><term>Olfaction</term><term>Olfaction Disorders (etiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Risk Factors</term><term>Risk factor</term><term>Visual hallucination</term><term>dementia</term><term>olfaction</term><term>visual hallucinations</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Dyskinesias</term><term>Hallucinations</term><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Confidence Intervals</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Middle Aged</term><term>Odors</term><term>Risk Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Complication</term><term>Démence</term><term>Facteur risque</term><term>Hallucination visuelle</term><term>Homme</term><term>Maladie de Parkinson</term><term>Odeur</term><term>Olfaction</term><term>Pathologie du système nerveux</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olfactory deficits appear early in the course of Parkinson's disease (PD) but their prognostic significance is not known. The goal of this study was to determine whether the severity of olfactory impairment is associated with subsequent risk of developing complications of PD. One hundred patients with PD self‐administered the University of Pennsylvania Smell Identification Test (UPSIT). Testing was done, on average, 3.6 years from the time of initial diagnosis. The incidence of neuropsychiatric features of PD, including cognitive decline and visual hallucinations, was ascertained through chart review after an average of 6.8 years of follow‐up. Incidence of motor outcomes including falls and dyskinesias was also obtained. There was a significant trend for increased risk of neuropsychiatric complications across declining quartiles of olfactory test scores. In addition, subjects in the lowest quartile of olfactory performance had a significantly higher adjusted risk of hallucinations (HR = 4.70, 95% CI 1.64, 13.42) and cognitive decline (HR = 3.10, 95% CI 1.05, 9.21) than those in the reference quartile. There was no association between olfactory dysfunction and dyskinesias, and a very modest association with risk of falls. These findings suggest that severity of olfactory impairment early in the disease course may be a useful marker for the risk of neuropsychiatric complications of PD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Kentucky</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Stephenson, Randolph" sort="Stephenson, Randolph" uniqKey="Stephenson R" first="Randolph" last="Stephenson">Randolph Stephenson</name></region><name sortKey="Doty, Richard L" sort="Doty, Richard L" uniqKey="Doty R" first="Richard L." last="Doty">Richard L. Doty</name><name sortKey="Houghton, David" sort="Houghton, David" uniqKey="Houghton D" first="David" last="Houghton">David Houghton</name><name sortKey="Siderowf, Andrew" sort="Siderowf, Andrew" uniqKey="Siderowf A" first="Andrew" last="Siderowf">Andrew Siderowf</name><name sortKey="Siderowf, Andrew" sort="Siderowf, Andrew" uniqKey="Siderowf A" first="Andrew" last="Siderowf">Andrew Siderowf</name><name sortKey="Stern, Matthew" sort="Stern, Matthew" uniqKey="Stern M" first="Matthew" last="Stern">Matthew Stern</name><name sortKey="Sundarararjan, Sri" sort="Sundarararjan, Sri" uniqKey="Sundarararjan S" first="Sri" last="Sundarararjan">Sri Sundarararjan</name><name sortKey="Xie, Sharon X" sort="Xie, Sharon X" uniqKey="Xie S" first="Sharon X." last="Xie">Sharon X. Xie</name><name sortKey="Xie, Sharon X" sort="Xie, Sharon X" uniqKey="Xie S" first="Sharon X." last="Xie">Sharon X. Xie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B42 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B42 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:3731A899623CB2E0CEE10F1B602A89581A3A3017
|texte= Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |